GREEN ANTIBIOTICS INNOVATION

Leadership, Expertise and Proof of Concept

At Avix Pharmaceuticals Limited, innovation and expertise drive our mission. Led by distinguished drug discovery scientists Dr. David Brown and Dr. Md Arif Sheikh, our diverse and skilled team strives to transform healthcare. With over 40 years of industry experience, Dr. Brown provides invaluable strategic insights.

Dr. Brown's paper in Nature introduced Antibiotic Resistance Breakers (ARBs), demonstrating that co-administering non-antibiotic drugs with antibiotics can overcome resistance. Our studies show that plant extract combinations, like ARB cocktail A1 and B1 (an IP-secret tetracycline formulation), can restore tetracycline's effectiveness against resistant Staphylococcus aureus and Salmonella typhi (picture below). We have 41 cocktails are ready to test which are formulated by Dr Sheikh and Dr Brown.

Staphylococcus aureus is a Gram-positive bacterium that is commonly found on the skin and mucous membranes of humans and animals. In the poultry industry, it can cause both animal and human infections.

Salmonella typhi is a Gram-negative bacterium that causes typhoid fever in humans. While Salmonella typhi is specifically adapted to humans, the broader genus Salmonella includes many serotypes that affect poultry and pose significant risks to human health.

OUR STRATEGY

Benefits of Green Antibiotics

Safe and Natural

Green antibiotics are derived from plants, ensuring a natural and safe alternative to synthetic antibiotics.

Effective Against AMR

Our green antibiotics target antibiotic-resistant bacteria at their source, reducing the spread of AMR and preserving the effectiveness of existing antibiotics.

Economic Viability

By offering a sustainable antimicrobial option, green antibiotics support the economic viability of the aquaculture and poultry sectors, ensuring these industries can thrive without compromising public health.

Antibiotic Use in Animal Agriculture

Global Overview

• Total Usage: Over 70% of antibiotics sold globally are used in food production animals.

• Growth Projections: Use is expected to increase by 67% from 2010 to 2030, especially in middle-income countries.

Regional Insights

• United States: 80% of antibiotics are used in livestock.

• European Union: Banned antibiotics as growth promoters since 2006.

• China: Largest consumer, using 50% of global veterinary antibiotics.

• India: Rapid increase due to expanding animal agriculture industries.

Billion Dollar Market

Increased awareness of antimicrobial resistance (AMR) and stricter regulations on antibiotic use in agriculture drive demand for sustainable alternatives. Green antibiotics, derived from natural plant compounds, address both health and environmental concerns.

Market Drivers:

• Rising AMR Awareness: AMR dangers fuels the need of new innovation

• Regulatory Changes: Stricter regulations on livestock antibiotic use

• Consumer Demand: Preference for antibiotic free food production

• Economic Benefits: Green antibiotics has the opportunity to enter $200B aquaculture and $350B poultry sectors, maintaining productivity while complying with regulations.